Think Yotsuba but with a planarian*/human mutant four-year-old girl instead of one with green hair.

(*a planarian is a kind of non-parasitic flatworm organism)

Kenn's Comment: Read Yotsuba&! while doing shrooms and Angel dust. Yep, that's pretty much what you'll get . Jokes aside, this manga is similar to Yotsuba&! in that you've got a young child ignorant of the ways of the world, and getting into zany situations with her caretaker. People who liked Yotsuba&! will probably be okay with this series. Those who, god forbid, hated Yotsuba&! will most likely not like this. The manga just recently started serializing so I wouldn't make too many judgements yet.